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Cycling Approach: Some practitioners implement protocols such as 12 weeks on, 4-8 weeks off to theoretically prevent receptor desensitization, reduce long-term costs, or provide physiological breaks

Nature 351 , 8182 (1991)

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Gut-brain axis (GBA) is a bidirectional communication network between the gastrointestinal tract (GIT) and CNS, involving nervous, immune, and endocrine systems (13)