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In addition, many of the patients were receiving MTX in combination with other cytotoxic agents, which caused difficulties in attributing all adverse events to MTX therapy

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Simultaneously, the preservation of SAM levels maintains cellular capacity for critical methylation reactions including histone modifications, DNA methylation, and protein methylation that regulate gene expression and protein function

Previous studies have reported a significantly lower PPT of the most symptomatic limb in patients with plantar fasciopathy than in pain-free controls 37,38,39

Zhao YJ, Zhu WJ, Wang XW, Zhang LH, Lee HC