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Description
Schiavone FP, Pivetta G, Scalamonti S, et al

Mechanism: Inhibits serotonin reuptake and blocks 5-HTA receptors
Hcy interacts with cysteine-825 residues situated on the pro-insulin receptor within the endoplasmic reticulum (ER), thereby disrupting the formation of initial disulfide bonds

838 The binding of MCM stimulates the GTPase activity of MeaB dramatically, and thus the client functions as a GTPase activating protein (GAP), a finding nicely explained by the structure of the complex

Various recommendations exist and the exact need for biotin is not yet known (10)
