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In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]

when cortisol is spiking and GH secretion is suppressed mechanistically works against the peptide's intended action

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J., Moayedi M., and Linnstaedt S
In this case, the nonenzymatic antioxidants take over the fight against ROS
