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Although at moderate concentrations, the CO produced by HO has anti-inflammatory, antiproliferative, and vasodilatory activities, it is toxic at a very high concentration [96]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Ilani T, Strous RD, Fuchs S (2004) Dopaminergic regulation of immune cells via D3 dopamine receptor: a pathway mediated by activated T cells

In one study, tyramine and 2-oxoglutarate were increased in the urine from IC/BPS patients 20 while etiocholan-3-ol-17-one sulfate was observed to increase in a second study 19 , and phenylacetylglutamine was observed to increase in a third study 17

As expected, AptaCtrl exhibited no detectable binding to either BSA, CspZ or its functional mimic FhbA