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Role of Trimethylamine N-Oxide in Heart Failure

Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spectrometry method

[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Sochocka M., Ochnik M., Sobczyski M., Gbura K., Zambrowicz A., Naporowski P., Leszek J

Moreover, considering that carnitine metabolism produces TMAO, which has been recently recognized as a novel risk factor for cardiovascular diseases, the use of uncontrolled amounts of carnitine as dietary supplements must be carefully reviewed. "Since carnitine is often used by athletes with no clear understanding of its effects and risks, it becomes critical to provide information about the characteristics of this compound and its probable harmful effects on health," the researchers said

Dose Range: 50100 mg daily with gradual titration