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Description
The TMLHE gene is located on the X chromosome (Xq28) and is composed of 13 exons that generate two alternatively spliced mRNAs that encode precursor proteins of 421 amino acids (isoform 1) and 376 amino acids (isoform 2)
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Wang L, Wang C, Gao X, Xu N, Lin L, Zhao H, et al
However, the expression of xCT can be induced in many types of cells in response to stress conditions such as oxidative stress and hyperoxia, which are likely mediated by transcriptional regulatory factors Nrf2 and ATF4 [51,52]
Post-COVID pulmonary sequelae: mechanisms and potential targets to reduce persistent fibrosis
