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Clinical Research Findings: SUSTAIN and PIONEER Trials A comprehensive safety analysis of 11,159 patients with type 2 diabetes across the SUSTAIN and PIONEER phase IIIa clinical trial programs found that gastrointestinal disorders occurred in 41.9% of patients receiving subcutaneous semaglutide and 39.1% receiving oral semaglutide, compared to 22.0% and 24.8% in comparator groups, respectively

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Reducing the Supply of NAD+ May Harm All Living CellsNot Just Cancer Cells Given cancer cells reliance on NAD+, some researchers have explored NAMPT inhibitors as a way to reduce NAD+ levels and slow tumor growth.' While this approach can affect cancer cells, it also carries significant systemic risks