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29 In TJs, claudins assort themselves into membrane strands via homo- or heteromeric interaction, and two anti-parallel strands connect to form the pore-like structure regulating the paracellular movement of small molecules

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As the macrocycle is systematically varied from 24-crown-8 to benzo-24-crown-8 and further to dibenzo-24-crown-8, higher temperatures are required to achieve comparable half-lives