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Because of its central role in energy metabolism, NAD+ and the enzymes controlling its production have become important areas of study in cancer biology

Importantly, IGF1R expression also determine RCC aggressiveness, while patients with clear-cell RCC shown kidney IGF1R expression higher than 50% have shorter survival time, a difference that becomes particularly significant after two years of follow-up.40 Moreover, after adjustment for age and stage at diagnosis, those patients with renal IGF1R expression higher than 50% had a 4.2 increased risk of death compared to those with lower renal IGF1R expression

It's thought to support angiogenesis (that's blood vessel creation), which plays a role in the body's natural recovery processes

Rhodiola rosea in stress-induced fatigue: A double-blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty

That idea has enough biologic plausibility to be interesting