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Oxidative and nitrosative stress, alongside increased neuronal apoptosis, are frequently observed in affected brain regions

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The pathogenesis of bullous morphea is unknown, but it is generally thought to be an autoimmune disorder, and treatment of coexistent ulcers can be challenging

Glutathione plays a critical role in reducing oxidative stress and supporting liver function, but levels can decline due to aging, stress, and environmental exposure

10.1007/s10495-020-01601-9 198 RavindranathanP.PashamD.GoelA