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The Gstz1 knockout mice excreted high levels of maleylacetone, fumarylacetone and succinylacetone in urine, while wild type mice did not excrete fumarylacetone or succinylacetone, and excreted much lower levels of maleylacetone

Set2 is required for proper function of the TOR pathway and thus implicated in regulating the transcriptional response to nutrient stress (McDaniel et al., 2017)
Role of Nrf2 and its activators in respiratory diseases

Thistlethwaite AJ, Leeper DB, Moylan DJ 3rd, Nerlinger RE

The metabolism of oxygen in mitochondria is associated with the production of superoxide, which damages cells
