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falciparum , further supporting the hypothesis that these drugs act by promoting the production of free radicals that are harmful to the parasite ( While increasing oxidative stress is an effective mechanism of action for parasite elimination, it may also have a negative impact on the host
Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation
doi: 10.1038/s41598-018-32138-2
325,326 This improvement is achieved through the inhibition of ferroptosis by downregulating ACSL4 expression via a PPAR--independent pathway
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