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Importantly, inhibition of TF-induced coagulation activation reduces microvascular stasis and lung vaso-occlusion in sickle mice (140)

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In line with the decreased PKM2 expression, HIF1 KO cells showed increased synthesis of serine and glycine as reflected by the integration of 13 C-glucose-derived 13 C-labeled carbons into serine and glycine, m + 3 and m + 2, respectively (Fig