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doi: 10.1371/journal.pone.0004589
When folic acid builds up in the body, it can actually slow down the methylation cycle and even interfere with HNMT (histamine N-methyltransferase) , the enzyme that helps break down histamine

Int J Pediatr Otorhinolaryngol 138:110322

The landscape of metabolic research is perpetually evolving, isn't it

The general practice is in cycles of supraphysiological doses which lead to fluctuating sexual dysfunction and depressed mood with emotional instability
