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22, G/D-CuP group exhibited a significantly reduced proportion of CD86-positive cells compared to the NC group
Skin fibroblasts expressing progerin exhibit: Flattened, irregular nuclei Increased oxidative stress Reduced collagen and elastin gene expression Slower cellular turnover UV radiation further accelerates progerin production in sun-exposed areas, which is why photoaged skin often appears older than biologically aged skin
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In some cases, epitalon appeared to reduce tumor incidence in animal models
