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Circulation of the BAs is highly dependent on transporting from the hepatocytes into biliary tracts, a process that is highly susceptible to perturbation from even minor liver damage indicating that they may be sensitive biomarkers of liver injury (Yamazaki et al

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6.2 Alkaloids 6.2.1 Berberine Berberine, an isoquinoline alkaloid from Berberis aristata , has been used for decades to treat intestinal parasites and enteropathogenic diarrhea due to its bactericidal activity, its ability to inhibit protozoan growth, and also to inhibit enterotoxin-induced intestinal electrolyte secretion (217219)

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Additionally, ex vivo exposure of amniotic fibroblasts to cortisol, endotoxin, or both led to increased 11-HSD1 expression (300)