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Targeting GPCRs and their signaling as a therapeutic option in melanoma

Author contributions XuL, LJ, XiL, DS and WY: study concept and design the overall study

Schlegel R

Male fertility issues are rising in Bangalore due to lifestyle, societal, and environmental factors: Extended working hours, chronic stress, poor sleep, sedentary behaviour and excess belly fat drive hormonal imbalance (low testosterone, raised insulin) and increased oxidative stress all of which directly harm sperm production, motility and DNA integrity

NOXs are a group of seven membrane-bound multi-component enzymes, namely NOX1, NOX2 (gp91phox), NOX3, NOX4, NOX5, DUOX1, and DUOX2, capable of oxidizing NADPH to NADP + , leading to the generation of superoxide by one-electron reduction of oxygen 14