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Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications

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His pain increased and he developed additional symptoms including nausea, lethargy, decreased appetite, constipation, decreased urinary stream, and a 57 kg weight loss

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A single intra-striatal injection of synthetic, misfolded -synuclein into multiple strains of wild-type mice initiates a neurodegenerative cascade characterized by the accumulation of intracellular Lewy body and Lewy neurite pathology, the selective loss of SNpc dopaminergic neurons, and impaired motor coordination [350]