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The progression of colitis was monitored using the Disease Activity Index (DAI) scoring system (Yao et al., 2020), which assesses the severity of colitis based on specific parameters

Iron-driven oxidation of dopamine results in the generation of 6-OHDA, which specifically inhibits mitochondrial complexes I and IV, leading to mitochondrial dysfunction (120)

tautomer refers to one of two or more structural isomers which exist in equilibrium and which are readily converted from one isomeric form to another

A review by Bump and Brown (1990) mentioned that radiation induces self-destructive damages in tissues, and most of such damages were initiated by oxidative radicals

In addition, FIN56 is capable of binding and activating squalene synthase, and leads to depleting coenzyme Q10 (CoQ10) (Shimada et al., 2016), which is a vital antioxidant by directly reducing lipid peroxyl radicals ( 2 , which is able to oxidate iron and indirectly inactivate GPX4, thus inducing lipid peroxidation in an ALOX-independent manner ( Connection Although the majority of current research regarding ferroptosis has focused on malignancies and degenerative diseases, there remain a few investigations on ferroptosis in cutaneous diseases