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8 December 2022

Peer review Peer review information Nature Reviews Urology thanks Ralf Henkel, Sandro Esteves and Luca Boeri for their contribution to the peer review of this work

Vitamin B12 supports brain health and neurotransmitter function, helping to stabilize mood and reduce feelings of anxiety or depression
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As erythrocytes lack intracellular organelles, their metabolism is restricted to well-known cytosolic biochemistry: glycolysis, the pentose phosphate pathway (PPP), redox metabolism, oxygen metabolism, purine/nucleoside metabolism, and membrane transport