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Artificial folic acid, which is contained in many dietary supplements, cannot be used directly

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Puche J.E., Castilla-Cortazar I
However, direct hormone replacement often bypasses the bodys natural endocrine feedback loops, leading to potential metabolic complications, receptor downregulation, and significant costs that limit long-term clinical utility

Further detailed in vitro experiments and preclinical studies in appropriate mouse models will be required to delineate if and how the two vitamins can be combined to achieve the best antitumor efficacy

, Perumalsamy, H
