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10.1111/bjh.14505 20 BhattR

Retrieved 2007-12-12

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Here we assign the agonist-dependent activation trigger at TM6 to the ligand-binding region of H264 6.54 F261 6.51 directly adjacent to the helix-kink at the CWxP 6.50 motif, which is involved in the known toggle-switch activation mechanism with the resulting TM6 movement typical for class A GPCRs (Fig