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Artemisinin has been shown to counteract this process by promoting apoptosis in parasite-infected cecal cells by increasing caspase-3 activity, a key enzyme in apoptosis execution, while decreasing Bcl-2 levels, a protein that inhibits apoptosis [89]

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While pre-existing immunity against Ad5 is reportedly widespread, its clinical application continues and moreover, alternative ChAdOx1 with low human seroprevalence have been derived for use as vaccine platforms 38,39