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There is also a loss of the usually sharp border between the red of the lip and the normal skin, known as the vermillion border

Clinical evidence pertaining to migraines, oxidative stress, and neurogenic inflammation, along with experimental evidence of topiramates antioxidative and anti-inflammatory effects, provide strong hypothetical support for the idea that topiramate may treat migraines by blocking oxidative stress and neurogenic inflammation pathways

Yu C, Gong AY, Chen D, Solelo Leon D, Young CY, Chen XM

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