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Increasing again during that window can make an otherwise workable dose intolerable

As a result, they have developed different mechanisms, such as reducing membrane permeability, efflux pump inhibition, modifying the target, and producing antibiotic-modifying enzymes that enhance their antimicrobial activity 5

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Peptide therapy with DAC is an exception, with a half-life of approximately 68 days, allowing for less frequent dosing