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The main manifestations of AD are cognitive impairment, memory loss, language, and behavior disorder, thereby harming the physical and mental health of patients

To investigate the regulatory effects of GLP-1RAs on cholesterol metabolism in hepatocytes treated with saturated free fatty acids, cells were pretreated with 400 M PA (Sigma-Aldrich) for 24 hours, followed by treatment with 100 nM exendin-4 (Sigma-Aldrich) or liraglutide (MedChemExpress) for an additional 24 hours

By profiling the expression of 5,736 proteins across four developmental stages, the study delineates the dynamic progression of organoid maturation and establishes a temporal framework for selecting functional timepoints

While ketone bodies are physiologic molecules, their high levels reduce the physiological pH of the blood and induce ketoacidosis, leading to increasing metabolic dysfunction

No significant hormonal disruption or blood pressure effects have been observed