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(91), in a 16-week randomized, double-blind, cross-over study with 27 adolescents suffering from migraines, suggested that dietary supplementation with fish oil rich in very long-chain omega-3 PUFAs could reduce the frequency, duration, and severity of migraines, a benefit also observed with olive oil

Timing of administration is important, with doses given 3060 minutes before meals to improve chewing and swallowing, or before bedtime to reduce morning weakness

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22

When taken orally, these compounds often fail to reach therapeutic concentrations in plasma and target tissues

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