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Meanwhile, natural multi-target neuraminidase inhibitors exert antiviral effects by regulating pathways such as Toll-like receptor 4 (TLR4) and Interleukin-6 (IL-6), significantly broadening the understanding of drug action mechanisms (Cao et al., 2024)

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Additional protocols make use of an adjuvant (e.g., aluminum hydroxide [HA]), which promotes a robust type 2 immune response (Th2) triggered by the immune system to more accurately reflect the clinical situation in patients [66]

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