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There is growing consensus that antioxidant-based strategies should progress beyond single-agent interventions and instead move toward multi-target approaches capable of simultaneously modulating redox balance, inflammatory pathways, and hypoxia-responsive signaling networks

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Clinical Research Findings In a comprehensive safety analysis published in 2013, researchers evaluated data from six randomized controlled trials spanning five years and involving approximately 900 adult participants

The incubation with antioxidants abrogated the anti-proliferative response, suggesting that the oxidative stress induced by fumarate accumulation is responsible for the induction of senescence

Mater Today Bio 26:101109 [DOI] [PMC free article] [PubMed] [Google Scholar] 175.Jalli R, Mehrabani D, Zare S, Saeedi Moghadam M, Jamhiri I, Manafi N, Mehrabani G, Ghabanchi J, Razeghian Jahromi I, Rasouli-Nia A et al (2023) Cell proliferation, viability, differentiation, and apoptosis of iron oxide labeled stem cells transfected with lipofectamine assessed by MRI