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Description
Gonzlez-Molina et al., 2022)
Glycine Glycine, synthesized from L-serine in the reversible reaction catalyzed by serine hydroxymethyltransferase, induces the opening of channels for chloride ions, hyperpolarization and decreased excitability of postsynaptic neurons
Additionally, this pathway upregulates the expression of NRF2, which can upregulate GPX4 expression [90]
Inhibiting PP2A as well as G6PD or activating Pax5 and Ikzf leads to reduced PPP activity sensitizing B-ALL cells to treatment (70)
Furthermore, necrotic tumor cells showed damaged mitochondria in proximity to the plasma membrane
