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However, very high doses from supplements or injections may lead to certain side effects in some individuals

Medication Interactions Certain medications reduce the absorption of methylcobalamin, cyanocobalamin, and other B12 supplements, including: Proton pump inhibitors (omeprazole, esomeprazole, and lansoprazole) H2-receptor antagonists (cimetidine, famotidine, and ranitidine) Metformin Colchicine Cholestyramine Certain antibiotics (neomycin and chloramphenicol) If you use these or other medications, talk with a healthcare provider about ways to maintain healthy levels of B12.

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Its unique structure distinguishes it from larger peptide chains traditionally used in metabolic research

In rare cases, starting high-dose B12 treatments for severe anemia may cause temporary imbalances in potassium levels or an acne-like rash