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The categorization of proteins with altered abundance in hypogonadic patients according to the information available at the Uniprot Knowledgebase revealed that 13 proteins were related to reproduction (18% of the total) ( Figure 1 )

doi: 10.3390/nu16040546 24 SharmaDGajjarDSeshadriS

This patient's symptoms are driven by elevated active T3 and T4, making thyroglobulin unlikely to be the mechanism

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An animal study showed that rats on a ketogenic diet during metabolic adaptation (approximately 3 weeks) exhibited increased production of H 2 O 2 originating from the hippocampus mitochondria and 4-hydroxynonenal (4-HNE), a product of lipid peroxidation