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Oncogene 38 , 47294738 (2019)

In experimental IBD, the DPP4 inhibitor, linagliptin, mitigates colitis by inhibiting colonic DPP4 activity, suppressing colonic IL-6, TNF-, and myeloperoxidase, and the upregulation of IL-10

This pathological state is like a double-edged sword: on the one hand, it may increase the passive penetration of polyphenols through the damaged mucosa, enhancing its local exposure

Intriguingly, CD8 + T cells exhibit an adaptive response by upregulating an alternative glutamine transporter, SLC6A14, thereby sustaining both glutamine uptake and immune effector function within V9302-treated tumors [134]

[DOI] [PubMed] [Google Scholar] 171.Janero DR