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For instance, aerobic glycolysis, carnitine and lipid synthesis, tryptophan metabolism are upregulated, whereas the urea cycle and tricarboxylic acid (TCA) cycle are downregulated [66]

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This is probably explained by the fact that S-adenosylmethionine (SAM), which is important for many epigenetic processes, is regenerated by methylcobalamin, whereas cyanocobalamin reduces it (as we explored above)

2 Grip Strength and Exercise Endurance in Aged Mice Dimet-Wiley et al., Scientific Reports (2024) This study compared 5-Amino-1MQ treatment, voluntary wheel-running exercise (PoWeR), and combined treatment in aged C57BL/6J mice