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205 A recent study showed that metformin can also regulate TJ-related protein expression by reducing the effects of TNF- on Caco-2 cell permeability, which results in inhibiting the MLCKMLC signaling pathway

Arch Biochem Biophys 385(1):2027

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Astaxanthin dosage Clinical studies on astaxanthin have tested a wide range of daily doses typically between 4mg and 12mg, though some trials extend up to 2040mg for short durations.11 36 38 45 Most human studies showing measurable benefits for oxidative stress, skin health, cognition, and eye comfort fall within the 612mg range.1 2 9 23 27 Doses at the higher end of that range appear to have the most consistent effects on markers of oxidative stress, such as MDA and increased SOD activity.22 37 Several studies examining exercise performance, sleep quality, cognition, and digital eye strain have also used 12mg daily.4 7 8 9 There is currently no official recommended daily intake for astaxanthin

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