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Maccioni L, Gao B, Leclercq S, Pirlot B, Horsmans Y, De Timary P, Leclercq I, Fouts D, Schnabl B, Strkel P

Harth G

The rats heads were then subjected to a single 10 Gy radiation dose 43 at a rate of 0.6213 kGy/h for 58 s while the rest of their bodies were shielded with lead

doi: 10.1212/WNL.0000000000003391 417 ZhangP

Its cytotoxic mode of action is mediated by its interaction with DNA to form DNA adducts, primarily intrastrand crosslink adducts, which activate several signal transduction pathways, including those involving ATR, p53, p73, and MAPK, and culminate in the activation of apoptosis
