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Studies demonstrate FOXO4-DRI achieves comparable renal function restoration to genetic clearance of senescent cells using the p16-3MR suicide gene system, confirming that therapeutic effects result specifically from senescent cell elimination rather than off-target actions

2012;56:133-48, ix

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[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Soliman S., Ahmed R.M., Ahmed M.M., Attia A., Soliman A.R
