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Studies suggest that this research area has expanded to include investigations of sexual arousal disorder mechanisms and potential therapeutic pathways

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The WHI estrogen plus progestin substudy reported increased risks of DVT, pulmonary embolism (PE), stroke and myocardial infarction (MI) in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral CE (0.625 mg) combined with medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo [see CLINICAL STUDIES and WARNINGS, Cardiovascular Disorders]

An independent pharmacist prepared and pre-labeled packs (each containing the drug that matched the assigned trial code)

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