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GLUTATHIONE S -DERIVATIVES ACTIVATED BY GT AND PEPTIDASES Gamma-glutamyl transferase (EC2.3.2.2) catalyzes the transpeptidation and hydrolysis of the -glutamyl group of GSH and related compounds to an acceptor molecule, including water, amino acids, and peptides

For instance, the transcription factors tumor protein p53 (TP53), activating transcription factor (ATF)3, BTB domain and CNC homolog 1 (BACH1) and STAT1 upregulate SLC7A11 and downregulate nuclear factor erythroid 2-related factor 2 (NFE2L2/Nrf2), ATF4 and aryl hydrocarbon receptor nuclear translocator-like protein 1

The decrease in GSH content usually disrupts the balance between cellular oxidative and antioxidative systems

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J Immunol (2007) 179:5291300