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Sempervirine also exhibits a synergistic effect with sorafenib, enhancing its anti-tumor efficacy in vivo by inhibiting -catenin and inducing tumor cell apoptosis

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Cytokine receptors Following their migration and extravasation from the bloodstream into the tissue, PMNs are rapidly activated by proinflammatory cytokines, which are detected by surface cytokine receptors (Kato and Kitagawa, 2006
