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Various METH dosing paradigms significantly disturb endothelial TJ assembly by inducing downregulation, fragmentation, or redistribution of major TJ proteins, including claudin-5 and ZO-1, which are mediated by MMP-1 and MMP-9 peptidases

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Some symptoms, from more minor to severe, impaired judgment and coordination walking difficulty slurred speech mood change behavior change nausea vomiting low body temperature memory loss double vision involuntary eye movement trouble breathing coma respiratory failure heart rhythm changes liver failure Chronic alcohol poisoning leads to alcohol-related liver disease

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Hemoglobin A1C is associated with increased risk of incident coronary heart disease among apparently healthy, nondiabetic men and women

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Others are early in preclinical research but show extraordinary promise

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Studies with these compounds require institutional oversight and safety protocols

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