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Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimers disease

ATP-binding cassette transporter A4 (ABCA4) facilitates the transport of atRAL from the outer segment discs of photoreceptors to the cytoplasm, while all-trans retinol dehydrogenase 8 (RDH8) catalyses the conversion of atRAL back to all-trans retinol (260)

In addition, it was reported that up-regulation of xCT through the mTOR pathway enhanced pheomelanin production and inhibited eumelanin formation, which altered the overall melanin synthesis in mice [92]

Yan W, Liu W, Qi J, Fang Q, Fan Z, Sun G, Han Y, Zhang D, Xu L, Wang M, Li J, Chen F, Liu D, Chai R, Wang H