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Severe loss of quality of life, due to symptoms such as debilitating fatigue, insomnia (B12 is required for synthesis of melatonin), mental illness, and neurological symptoms

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But this will subsequently decline soon thereafter, and further administrations of the drug are necessary to reach sufficient steady states

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Vercammen D, Brouckaert G, Denecker G, Van de Craen M, Declercq W, Fiers W, Vandenabeele P

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Once a suspicious stricture or mass is identified on MRI/MRCP, complementary testing is performed to support a diagnosis of CCA

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