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This is another huge fork in the road for researchers
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Acta Oncol (Madr)

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Meyer N, Penn LZ

Non-selective cation channel activity of aquaporin AtPIP2;1 regulated by Ca2+ and pH

Substituting arginine for glutamate at this position markedly reduces the analogs affinity for the IGFBPs while leaving its ability to engage the type 1 IGF receptor (IGF-1R) largely intact
