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Those most likely to benefit include: Individuals with diagnosed or suspected vitamin B12 deficiency

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TB-500 reconstitution follows a similar protocol: 12 mL of bacteriostatic water per 5 mg vial

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

Wrote or contributed to the writing of the manuscript: McCoy, Benoist, Wright, Kawas, Bule-Ghogare, Appleyard, Wayman, Harding