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A drug can be metabolized in the gut wall (eg, by the CYP3A4 enzyme system) or even in the portal blood, but most commonly it is the liver that is responsible for metabolism before the drug reaches the systemic circulation
On top of that, interactions of biomaterials with erythrocytes, which are the most abundant cells in circulation, are mainly evaluated by in vitro hemolysis testing [465, 466]

Future Directions and Research Implications