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This trial had certain limitations, and the efficacy of deferiprone in patients already on dopaminergic medications requires further validation

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These actions seem to be responsible for i) the downregulation of inflammatory cytokines and ii) an overall shift from a pro-inflammatory (Th1/Th17) response to an anti-inflammatory/regulatory (Th2) response

Notably, two such trials with low dose NAC, 600 mg/day over 3 years demonstrated some efficacy in inhaled corticosteroid (ICS)-nave patients only (28, 29)

Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates