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This is further enhanced by the inclusion of molecules such as integrins in the glycocalyx structure and their relationship with signaling molecules such as ion channels, caveolae signalosomes and focal adhesion-associated kinases (7, 14, 43, 203, 321)

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Cofactor formation was much slower than the rates reported for other amino acid cofactor-containing enzymes and, in fact, took hundreds of catalytic turnover cycles to occur

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