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In recent years, ample evidence has linked DED with lifestyle, highlighting the impact of exercise, diet, and sleep on its development (31)

doi: 10.3390/diagnostics9030082 [DOI] [PMC free article] [PubMed] [Google Scholar] 77

In addition, mechanisms of MOR-EGFR transactivation by these agonists all required similar mechanisms of CaM recruitment and PKC signaling, although they had been characterized as opioids with different signaling bias toward G protein and -arrestin recruitment (Schmid et al., 2017)